Cfhr1^em1Wli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cfhr1^em1Wli
• Name: complement factor H-related 1; endonuclease-mediated mutation 1, Wei Li
• MGI ID: MGI:8276744
• Gene: Cfhr1 Location: Chr1:139474802-139487960 bp, - strand Genetic Position: Chr1, 61.62 cM
• Alliance: Cfhr1^em1Wli page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated recombination created a deletion spanning exons 1 - 5. (J:303926)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfhr1 Mutation: 25 strains or lines available

References

• Original: J:303926 Li X, et al., Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway. Front Immunol. 2020;11:1123
• All: 2 reference(s)