Ints11^tm1.2Shra
Targeted Allele Detail

Summary

• Symbol: Ints11^tm1.2Shra
• Name: integrator complex subunit 11; targeted mutation 1.2, Ramin Shiekhattar
• MGI ID: MGI:8276548
• Gene: Ints11 Location: Chr4:155954006-155973561 bp, + strand Genetic Position: Chr4, 87.66 cM
• Alliance: Ints11^tm1.2Shra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:370644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Recombinase-mediated recombination removed the neo cassette and exon 2. (J:370644)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ints11 Mutation: 34 strains or lines available

References

• Original: J:370644 Edupuganti RR, et al., Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development. Mol Cell. 2025 Aug 7;85(15):2937-2955.e10
• All: 1 reference(s)