Recql4^tm1.1Brle
Targeted Allele Detail

Summary

• Symbol: Recql4^tm1.1Brle
• Name: RecQ protein-like 4; targeted mutation 1.1, Brendan Lee
• MGI ID: MGI:8275291
• Synonyms: Recql4^fl
• Gene: Recql4 Location: Chr15:76587753-76594748 bp, - strand Genetic Position: Chr15, 36.28 cM, cytoband D3
• Alliance: Recql4^tm1.1Brle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309253
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 8. The neomycin cassette was removed via flp-mediated recombination, leaving exons 5-8 floxed. (J:309253)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Recql4 Mutation: 53 strains or lines available

References

• Original: J:309253 Lu L, et al., RECQL4 Regulates p53 Function In Vivo During Skeletogenesis. J Bone Miner Res. 2015 Jun;30(6):1077-89
• All: 2 reference(s)