Orai1^em2Dirr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Orai1^em2Dirr
• Name: ORAI calcium release-activated calcium modulator 1; endonuclease-mediated mutation 2, Robert T Dirksen
• MGI ID: MGI:8273508
• Synonyms: Orai1^V5HA
• Gene: Orai1 Location: Chr5:123153137-123168519 bp, + strand Genetic Position: Chr5, 62.72 cM
• Alliance: Orai1^em2Dirr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/cas9-mediated recombination inserted a V5-3xHA epitope tag in the extreme C-terminus of the protein. (J:376832)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Orai1 Mutation: 22 strains or lines available

References

• Original: J:376832 Zhao N, et al., An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease. EMBO J. 2024 Dec;43(23):5941-5971
• All: 1 reference(s)