Prdm1^{em1(cre/ERT2)Mcdl}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prdm1^{em1(cre/ERT2)Mcdl}
• Name: PR domain containing 1, with ZNF domain; endonuclease-mediated mutation 1, Maria A Curotto de Lafaille
• MGI ID: MGI:8270889
• Synonyms: Prdm1^CreERT2
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^{em1(cre/ERT2)Mcdl} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Prdm1^{em1(cre/ERT2)Mcdl} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prdm1 (MGI:99655)

• Mutation details: CRISPR/Cas9 genome editing technology was used to replace the stop codon of the gene in exon 7 with a 2A ribosomal skipping sequence linked to the creERT2 coding sequence. (J:376450)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prdm1 (mouse) Summary of all recombinase alleles driven by Prdm1. Alliance mouse Prdm1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 69 strains or lines available

References

• Original: J:376450 Miranda-Waldetario MCG, et al., Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response. Immunity. 2025 Nov 11;58(11):2717-2733.e7
• All: 1 reference(s)