Egr2^{em1(cre/ERT2)Lql}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Egr2^{em1(cre/ERT2)Lql}
• Name: early growth response 2; endonuclease-mediated mutation 1, Lu Q Le
• MGI ID: MGI:8270883
• Synonyms: Krox20-CreERT
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^{em1(cre/ERT2)Lql} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Egr2^{em1(cre/ERT2)Lql} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Egr2 (MGI:95296)

• Mutation details: CRISPR/cas9-mediated mediated recombination inserted a P2A-cre/ERT2 cassette after the last coding sequence of the gene. (J:358836)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Egr2 (mouse) Summary of all recombinase alleles driven by Egr2. Alliance mouse Egr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 32 strains or lines available

References

• Original: J:358836 Ghotbi E, et al., Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation. J Clin Invest. 2024 Oct 3;134(23)
• All: 2 reference(s)