S1pr5^{tm1.1(cre)Moli}
Targeted Allele Detail

Summary

• Symbol: S1pr5^{tm1.1(cre)Moli}
• Name: sphingosine-1-phosphate receptor 5; targeted mutation 1.1, Ming Li
• MGI ID: MGI:8270810
• Synonyms: S1pr5^{eGFP-T2A-iCre}
• Gene: S1pr5 Location: Chr9:21154213-21159739 bp, - strand Genetic Position: Chr9, 7.75 cM, cytoband A4
• Alliance: S1pr5^{tm1.1(cre)Moli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:352601
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• S1pr5^{tm1.1(cre)Moli} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	S1pr5 (MGI:2150641)

• Mutation details: An IRES-EGFP-T2A-Cre-frt-NEO-BGHpA-frt sequence was inserted into the S1pr5 3' UTR by homologous recombination in ES cells. Mice were bred to FLPeR mice to excise the NEO cassette. (J:352601)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	S1pr5 (mouse) Summary of all recombinase alleles driven by S1pr5. Alliance mouse S1pr5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S1pr5 Mutation: 19 strains or lines available

References

• Original: J:352601 Nixon BG, et al., Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Sci Immunol. 2022 Apr 8;7(70):eabi8642
• All: 2 reference(s)