Phf6^{em1(cre/ERT2)Huaj}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Phf6^{em1(cre/ERT2)Huaj}
• Name: PHD finger protein 6; endonuclease-mediated mutation 1, Ju Huang
• MGI ID: MGI:8268626
• Synonyms: Phf6-CreER
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^{em1(cre/ERT2)Huaj} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Phf6^{em1(cre/ERT2)Huaj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Phf6 (MGI:1918248)

• Mutation details: CRISPR/cas9-mediated recombination inserted an IRES-cre/ERT2 cassette immediately downstream of the TAG stop codon in exon 10. (J:375655)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Phf6 (mouse) Summary of all recombinase alleles driven by Phf6. Alliance mouse Phf6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:375655 Liu B, et al., Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe. Mol Psychiatry. 2025 Oct 6
• All: 1 reference(s)