Kcnd3^em1Tfts
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnd3^em1Tfts
• Name: potassium voltage-gated channel, Shal-related family, member 3; endonuclease-mediated mutation 1, Ting-Fen Tsa
• MGI ID: MGI:8266575
• Synonyms: Kcnd3^-
• Gene: Kcnd3 Location: Chr3:105359646-105581318 bp, + strand Genetic Position: Chr3, 46.32 cM, cytoband F3
• Alliance: Kcnd3^em1Tfts page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2, which contains the start codon and most of the coding region, was deleted using CRISPR/Cas9 technology. (J:363793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnd3 Mutation: 62 strains or lines available

References

• Original: J:363793 Hung HC, et al., A dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning. J Pathol. 2025 Jan;265(1):57-68
• All: 1 reference(s)