Trpv6^{tm1.1(cre)Mfre}
Targeted Allele Detail

Summary

• Symbol: Trpv6^{tm1.1(cre)Mfre}
• Name: transient receptor potential cation channel, subfamily V, member 6; targeted mutation 1.1, Marc Freichel
• MGI ID: MGI:8266553
• Synonyms: Trpv6^IC
• Gene: Trpv6 Location: Chr6:41597558-41613339 bp, - strand Genetic Position: Chr6, 19.79 cM, cytoband B2
• Alliance: Trpv6^{tm1.1(cre)Mfre} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294971
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (No functional change, Recombinase)
• Mutation: Insertion
• Trpv6^{tm1.1(cre)Mfre} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trpv6 (MGI:1927259)

• Mutation details: An internal ribosome entry site (IRES) sequence followed by a Cre recombinase cDNA was inserted after the final stop codon. This sequence is followed by an FRT-flanked pgk-promotordriven neomycin resistance gene cassette and a Flp-ACE cassette which directed self-induced deletion of these DNA sequences in the male germ line. (J:294971)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trpv6 (mouse) Summary of all recombinase alleles driven by Trpv6. Alliance mouse Trpv6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv6 Mutation: 33 strains or lines available

References

• Original: J:294971 Fecher-Trost C, et al., Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
• All: 3 reference(s)