Cdadc1^em1Boch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdadc1^em1Boch
• Name: cytidine and dCMP deaminase domain containing 1; endonuclease-mediated mutation 1, Matthias Bochtler
• MGI ID: MGI:8261286
• Synonyms: Cdadc1^Glu401Ala
• Gene: Cdadc1 Location: Chr14:59796837-59835408 bp, - strand Genetic Position: Chr14, 31.48 cM, cytoband C3
• Alliance: Cdadc1^em1Boch page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a single nucleotide A to C substitution resulting in a glutamine to alanine substitution at amino acid 401 (p.E401A). In addition, a silent mutation in Ala400 was introduced to destroy the PAM sequence. E401A in mouse corresponds to E400A in human. (J:372389)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdadc1 Mutation: 29 strains or lines available

References

• Original: J:372389 Slyvka A, et al., Activity and structure of human (d)CTP deaminase CDADC1. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2424245122
• All: 1 reference(s)