Scn11a^{em1(icre)Itsu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn11a^{em1(icre)Itsu}
• Name: sodium channel, voltage-gated, type XI, alpha; endonuclease-mediated mutation 1, Isao Tsuneyoshi
• MGI ID: MGI:8261240
• Synonyms: NaV1.9-iCre, NaV1.9^iCre
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^{em1(icre)Itsu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Scn11a^{em1(icre)Itsu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scn11a (MGI:1345149)

• Mutation details: CRISPR/cas9-mediated recombination inserted a P2A-iCre-rabbit globin polyadenylation sequence after the termination codon. (J:365780)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scn11a (mouse) Summary of all recombinase alleles driven by Scn11a. Alliance mouse Scn11a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 89 strains or lines available

References

• Original: J:365780 Maruta T, et al., Comparison of Nocifensive Behavior in Na(V)1.7-, Na(V)1.8-, and Na(V)1.9-Channelrhodopsin-2 Mice by Selective Optogenetic Activation of Targeted Sodium Channel Subtype-Expressing Afferents. J Neurosci Res. 2024 Oct;102(10):e25386
• All: 1 reference(s)