Nos1^tm1(cre)Nbio
Targeted Allele Detail

Summary

• Symbol: Nos1^tm1(cre)Nbio
• Name: nitric oxide synthase 1, neuronal; targeted mutation 1, National Institute of Biomedical Innovation
• MGI ID: MGI:8261062
• Gene: Nos1 Location: Chr5:118004904-118096905 bp, + strand Genetic Position: Chr5, 57.29 cM, cytoband F
• Alliance: Nos1^tm1(cre)Nbio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:372572
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nos1^tm1(cre)Nbio expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nos1 (MGI:97360)

• The knock-in allele contains a cre-SV40 polyA sequence at the start codon of exon 1. (J:372572)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nos1 (mouse) Summary of all recombinase alleles driven by Nos1. Alliance mouse Nos1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos1 Mutation: 86 strains or lines available

References

• Original: J:372572 Kashiwagi M, et al., A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Cell. 2024 Oct 31;187(22):6272-6289.e21
• All: 1 reference(s)