Higd1b^{tm1.1(cre/ERT2)Que}
Targeted Allele Detail

Summary

• Symbol: Higd1b^{tm1.1(cre/ERT2)Que}
• Name: HIG1 domain family, member 1B; targeted mutation 1.1, Jianwen Que
• MGI ID: MGI:8259644
• Synonyms: Higd1b^{creERT2-P2A-EGFP}
• Gene: Higd1b Location: Chr11:102726675-102728866 bp, + strand Genetic Position: Chr11, 66.48 cM, cytoband D
• Alliance: Higd1b^{tm1.1(cre/ERT2)Que} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:367435
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Higd1b^{tm1.1(cre/ERT2)Que} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Higd1b (MGI:1922939)

• Mutation details: A construct containing an cre/ERT2-P2A-EGFP cassette and FRT-flanked neo cassette was inserted to replace the start codon in exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:367435)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Higd1b (mouse) Summary of all recombinase alleles driven by Higd1b. Alliance mouse Higd1b gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Higd1b Mutation: 3 strains or lines available

References

• Original: J:367435 Fang Y, et al., RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition. Nature. 2025 Apr;640(8057):221-230
• All: 1 reference(s)