Il17ra^{em1(flpo)Gcho}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il17ra^{em1(flpo)Gcho}
• Name: interleukin 17 receptor A; endonuclease-mediated mutation 1, Homayon Ghiasi
• MGI ID: MGI:8259625
• Synonyms: Il-17ra-FlpO
• Gene: Il17ra Location: Chr6:120440143-120460692 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Il17ra^{em1(flpo)Gcho} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Il17ra^{em1(flpo)Gcho} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il17ra (MGI:107399)

• CRISPR/cas9-mediated recombination inserted a flpo cassette into exon 13 adjacent to the 3' UTR. (J:367654)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il17ra (mouse) Summary of all recombinase alleles driven by Il17ra. Alliance mouse Il17ra gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17ra Mutation: 47 strains or lines available

References

• Original: J:367654 Lee B, et al., Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety. Cell. 2025 Apr 17;188(8):2190-2202.e15
• All: 1 reference(s)