Hdc^{em2(cre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdc^{em2(cre/ERT2)Smoc}
• Name: histidine decarboxylase; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:8259259
• Synonyms: HDC-creERT2, Hdc^{em(2A-CreERT2)Smoc}
• Gene: Hdc Location: Chr2:126435587-126461219 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband E5-G
• Alliance: Hdc^{em2(cre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Hdc^{em2(cre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hdc (MGI:96062)

• CRISPR/cas9-mediated recombination inserted a 2A-cre/ERT2 cassette into the stop codon of the gene. (J:279175, J:347502)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hdc (mouse) Summary of all recombinase alleles driven by Hdc. Alliance mouse Hdc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdc Mutation: 52 strains or lines available

References

• Original: J:347502 Xu L, et al., An H2R-dependent medial septum histaminergic circuit mediates feeding behavior. Curr Biol. 2022 May 9;32(9):1937-1948.e5
• All: 4 reference(s)