Gfap^{em1(dre/ERT2)Guow}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gfap^{em1(dre/ERT2)Guow}
• Name: glial fibrillary acidic protein; endonuclease-mediated mutation 1, Weixiang Guo
• MGI ID: MGI:8256896
• Synonyms: GFAP-DreER^T2
• Gene: Gfap Location: Chr11:102778162-102791368 bp, - strand Genetic Position: Chr11, 66.48 cM, cytoband D
• Alliance: Gfap^{em1(dre/ERT2)Guow} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Gfap^{em1(dre/ERT2)Guow} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• Mutation details: CRISPR/cas9-mediated recombination replaced the initiation codon with a dre/ERT2-WPRE-SV40-pA cassette. (J:373293)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Alliance mouse Gfap gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfap Mutation: 49 strains or lines available

References

• Original: J:373293 Liang Z, et al., Dual recombinase-mediated intersectional genetics defines the functional heterogeneity of neural stem cells in adult hippocampus. Mol Psychiatry. 2025 Aug;30(8):3516-3532
• All: 1 reference(s)