Cdh5^{tm1(icre/ERT2)Bcgen}
Targeted Allele Detail

Summary

• Symbol: Cdh5^{tm1(icre/ERT2)Bcgen}
• Name: cadherin 5; targeted mutation 1, Biocytogen LLC
• MGI ID: MGI:8256887
• Synonyms: Cdh5-CreER
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^{tm1(icre/ERT2)Bcgen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:373634
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cdh5^{tm1(icre/ERT2)Bcgen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdh5 (MGI:105057)

• Mutation details: An icre/ERT2 cassette was inserted at the end of the coding sequence in exon 2 via homologous recombination. (J:308681)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (mouse) Summary of all recombinase alleles driven by Cdh5. Alliance mouse Cdh5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 54 strains or lines available

References

• Original: J:373634 Huang D, et al., ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021 Jan 4;131(1)
• All: 4 reference(s)