Calcb^{tm1.1(cre/ERT2)Raom}
Targeted Allele Detail

Summary

• Symbol: Calcb^{tm1.1(cre/ERT2)Raom}
• Name: calcitonin-related polypeptide, beta; targeted mutation 1.1, Meenakshi Rao
• MGI ID: MGI:8255275
• Synonyms: Calcb^CreER, Calcb^ERT-cre
• Gene: Calcb Location: Chr7:114317878-114322600 bp, + strand Genetic Position: Chr7, 60.19 cM, cytoband F3
• Alliance: Calcb^{tm1.1(cre/ERT2)Raom} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:367693
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Calcb^{tm1.1(cre/ERT2)Raom} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Calcb (MGI:2151254)

• Mutation details: A construct containing a cre/ERT2 cassette and an FRT-neo-FRT-loxP cassette was inserted in place of the first 89 bp of exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:367693)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Calcb (mouse) Summary of all recombinase alleles driven by Calcb. Alliance mouse Calcb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcb Mutation: 15 strains or lines available

References

• Original: J:367693 Barilla RM, et al., Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science. 2025 May 22;:eadn9850
• All: 1 reference(s)