Ms4a4a^em1Cmk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ms4a4a^em1Cmk
• Name: membrane-spanning 4-domains, subfamily A, member 4A; endonuclease-mediated mutation 1, Celeste M Karch
• MGI ID: MGI:8254779
• Synonyms: Ms4a4a^-
• Gene: Ms4a4a Location: Chr19:11352887-11370154 bp, + strand Genetic Position: Chr19, 8.44 cM
• Alliance: Ms4a4a^em1Cmk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting intronic regions 5' to exon 1 and 3' to the stop codon in exon 7 resulted in a deletion of exons 1-7. (J:371923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a4a Mutation: 17 strains or lines available

References

• Original: J:371923 Danhash EP, et al., Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation. Alzheimers Dement. 2025 Aug;21(8):e70580
• All: 1 reference(s)