Gt(ROSA)26Sor^{em1(CAG-dre)Ylu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-dre)Ylu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Youming Lu
• MGI ID: MGI:8252959
• Synonyms: C on /F off -DRE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-dre)Ylu} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Recombinase)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-dre)Ylu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A pCAG-LoxP-STOP-LoxP-FRT-DRE-FRT-WPRE-pA construct was inserted in the gene. Expression of dre is turned on by cre-mediated removal of the STOP sequence. Flp-mediated removal the the dre sequence will turn off dre expression. (J:350514)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:350514 Li X, et al., Molecularly defined and functionally distinct cholinergic subnetworks. Neuron. 2022 Nov 16;110(22):3774-3788.e7
• All: 2 reference(s)