Npas4^{em1(cre/ERT2)Cwco}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Npas4^{em1(cre/ERT2)Cwco}
• Name: neuronal PAS domain protein 4; endonuclease-mediated mutation 1, Christopher W Cowan
• MGI ID: MGI:8250569
• Synonyms: NPAS4-TRAp2a
• Gene: Npas4 Location: Chr19:5034383-5040344 bp, - strand Genetic Position: Chr19, 4.2 cM
• Alliance: Npas4^{em1(cre/ERT2)Cwco} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Npas4^{em1(cre/ERT2)Cwco} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npas4 (MGI:2664186)

• CRISPR/cas9-mediated recombination inserted a P2A-cre/ERT2 cassette fused to gene. (J:366967)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npas4 (mouse) Summary of all recombinase alleles driven by Npas4. Alliance mouse Npas4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas4 Mutation: 25 strains or lines available

References

• Original: J:366967 Hughes BW, et al., NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens. Nat Commun. 2024 Aug 8;15(1):5971
• All: 1 reference(s)