Omd^tm1.1Sohm
Targeted Allele Detail

Summary

• Symbol: Omd^tm1.1Sohm
• Name: osteomodulin; targeted mutation 1.1, Shin-Ichi Ohnuma
• MGI ID: MGI:8249491
• Synonyms: Omd^-, Omd^LacZ
• Gene: Omd Location: Chr13:49735938-49746088 bp, + strand Genetic Position: Chr13, 25.33 cM
• Alliance: Omd^tm1.1Sohm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector inserted a LoxP sequence upstream of exon 2 (containing the initiation codon). A neomycin resistant unit, second LoxP sequence, and a LacZ reporter cassette were inserted downstream of exon 3. Cre-mediated recombination in ES cells removed exons 2 and 3 and the selection cassette to generate a null reporter allele. (J:342336)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Omd Mutation: 31 strains or lines available

References

• Original: J:342336 Davaapil H, et al., PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity. Front Cell Dev Biol. 2023;11:1147625
• All: 2 reference(s)