Prelp^tm1.1Sohm
Targeted Allele Detail

Summary

• Symbol: Prelp^tm1.1Sohm
• Name: proline arginine-rich end leucine-rich repeat; targeted mutation 1.1, Shin-Ichi Ohnuma
• MGI ID: MGI:8249485
• Synonyms: Prelp^-, Prelp^Lacz
• Gene: Prelp Location: Chr1:133838042-133849152 bp, - strand Genetic Position: Chr1, 58.02 cM
• Alliance: Prelp^tm1.1Sohm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector inserted a LoxP sequence upstream of exon 2 (containing the initiation codon). A neomycin resistant unit, second LoxP sequence, and a LacZ reporter cassette were inserted downstream of exon 3. Cre-mediated recombination in ES cells removed exons 2 and 3 and the selection cassette to generate a null reporter allele. (J:342336)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prelp Mutation: 36 strains or lines available

References

• Original: J:342336 Davaapil H, et al., PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity. Front Cell Dev Biol. 2023;11:1147625
• All: 2 reference(s)