Nkx2-3^{em1(cre/ERT2)Crxu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nkx2-3^{em1(cre/ERT2)Crxu}
• Name: NK2 homeobox 3; endonuclease-mediated mutation 1, Cheng-Ran Xu
• MGI ID: MGI:8249298
• Synonyms: Nkx2-3-CreERT2-EGFP
• Gene: Nkx2-3 Location: Chr19:43600764-43604331 bp, + strand Genetic Position: Chr19, 36.67 cM
• Alliance: Nkx2-3^{em1(cre/ERT2)Crxu} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, No functional change, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Nkx2-3^{em1(cre/ERT2)Crxu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx2-3 (MGI:97348)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a P2A-CreERT2-P2A-EGFP sequence before the translation stop codon of the target gene. (J:361676)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-3 (mouse) Summary of all recombinase alleles driven by Nkx2-3. Alliance mouse Nkx2-3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-3 Mutation: 14 strains or lines available

References

• Original: J:361676 Li KR, et al., Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution. Cell. 2025 Feb 6;188(3):796-813.e24
• All: 1 reference(s)