Tph1^{tm1.1(Cre/ERT2)Rosay}
Targeted Allele Detail

Summary

• Symbol: Tph1^{tm1.1(Cre/ERT2)Rosay}
• Name: tryptophan hydroxylase 1; targeted mutation 1.1, Kenton M Sanders and Seungil Ro
• MGI ID: MGI:8249225
• Synonyms: Tph1^CreERT2
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^{tm1.1(Cre/ERT2)Rosay} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:372520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tph1^{tm1.1(Cre/ERT2)Rosay} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tph1 (MGI:98796)

• Mutation details: A cre recombinase gene was fused to a modified estrogen receptor (CreERT2) and inserted to the end of the open reading frame of the Tph1 gene at exon 11 with a self-cleaving peptide, T2A. An frt-flanked kan/neo selection cassette was removed via FLP-mediated recombination in the germline. (J:372520)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tph1 (mouse) Summary of all recombinase alleles driven by Tph1. Alliance mouse Tph1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 42 strains or lines available

References

• Original: J:372520 Wei L, et al., Serotonin Deficiency Is Associated With Delayed Gastric Emptying. Gastroenterology. 2021 Jun;160(7):2451-2466.e19
• All: 1 reference(s)