Pdgfra
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pdgfra
• Name: platelet derived growth factor receptor, alpha polypeptide; endonuclease-mediated mutation 1, University College London
• MGI ID: MGI:8249121
• Synonyms: Pdgfra-mGFP-CreERT2
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase, Reporter)
• Mutation: Insertion
• Pdgfra expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfra (MGI:97530)

• Mutation details: An EGFP reporter gene with a membrane tag (N-terminal 020 amino acids of neuromodulin GAP-43) followed by a CreERT2 cassette, linked to mGFP with a P2A self-cleavage peptide, was inserted into the Pdgfra gene using CRISPR/Cas9 genome editing technology. (J:330919)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfra (mouse) Summary of all recombinase alleles driven by Pdgfra. Alliance mouse Pdgfra gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 87 strains or lines available

References

• Original: J:330919 Horsnell HL, et al., Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics. Nat Immunol. 2022 Aug;23(8):1169-1182
• All: 1 reference(s)