Agrp^em1(dre)Jcbr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Agrp^em1(dre)Jcbr
• Name: agouti related neuropeptide; endonuclease-mediated mutation 1, Jens Bruning
• MGI ID: MGI:8249095
• Synonyms: Agrp-p2a-Dre
• Gene: Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
• Alliance: Agrp^em1(dre)Jcbr page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Agrp^em1(dre)Jcbr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Agrp (MGI:892013)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a p2a-Dre cassette at the site of the AgRP gene stop codon. (J:365619)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Agrp (mouse) Summary of all recombinase alleles driven by Agrp. Alliance mouse Agrp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agrp Mutation: 18 strains or lines available

References

• Original: J:365619 Porniece Kumar M, et al., Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 Dec;3(12):1662-1679
• All: 2 reference(s)