Hand1^{em1(cre/ERT2)Ncch}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hand1^{em1(cre/ERT2)Ncch}
• Name: heart and neural crest derivatives expressed 1; endonuclease-mediated mutation 1, Neil C Chi
• MGI ID: MGI:8249064
• Synonyms: Hand1-CreERT2
• Gene: Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
• Alliance: Hand1^{em1(cre/ERT2)Ncch} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase)
• Mutation: Insertion
• Hand1^{em1(cre/ERT2)Ncch} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hand1 (MGI:103577)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a P2a-CreERT2 construct into the second exon of the gene. (J:362605)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hand1 (mouse) Summary of all recombinase alleles driven by Hand1. Alliance mouse Hand1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand1 Mutation: 14 strains or lines available

References

• Original: J:362605 Zhang Q, et al., Unveiling Complexity and Multipotentiality of Early Heart Fields. Circ Res. 2021 Aug 6;129(4):474-487
• All: 1 reference(s)