Lypd1^{em1(cre/ERT2)Mll}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lypd1^{em1(cre/ERT2)Mll}
• Name: Ly6/Plaur domain containing 1; endonuclease-mediated mutation 1, Ulrich Muller
• MGI ID: MGI:8248018
• Synonyms: Lypd1-CreERT2
• Gene: Lypd1 Location: Chr1:125795359-125840838 bp, - strand Genetic Position: Chr1, 54.7 cM
• Alliance: Lypd1^{em1(cre/ERT2)Mll} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Lypd1^{em1(cre/ERT2)Mll} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lypd1 (MGI:1919835)

• Mutation details: CRISPR/Cas9 genomic editing was used to insert a 2TA cleavage peptide followed by Cre/ERT2 directly in front of the endogenous stop codon. (J:349269)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lypd1 (mouse) Summary of all recombinase alleles driven by Lypd1. Alliance mouse Lypd1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lypd1 Mutation: 16 strains or lines available

References

• Original: J:349269 Siebald C, et al., Molecular signatures define subtypes of auditory afferents with distinct peripheral projection patterns and physiological properties. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2217033120
• All: 2 reference(s)