Prdm1^{tm1(cre/ERT2)Dmta}
Targeted Allele Detail

Summary

• Symbol: Prdm1^{tm1(cre/ERT2)Dmta}
• Name: PR domain containing 1, with ZNF domain; targeted mutation 1, David M Tarlinton
• MGI ID: MGI:8245479
• Synonyms: Blimp1-TdT-CreERT, BLT-cre
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^{tm1(cre/ERT2)Dmta} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:364893
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Prdm1^{tm1(cre/ERT2)Dmta} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prdm1 (MGI:99655)

• Mutation details: A construct carrying an exon comprising IRES-TdTomato-P2A-CreERT2 was inserted between exons 6 and 7. (J:364893)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prdm1 (mouse) Summary of all recombinase alleles driven by Prdm1. Alliance mouse Prdm1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 69 strains or lines available

References

• Original: J:364893 Robinson MJ, et al., Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response. Sci Immunol. 2022 Oct 28;7(76):eabm8389
• All: 2 reference(s)