Syt2^em1(cre)Crni
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syt2^em1(cre)Crni
• Name: synaptotagmin II; endonuclease-mediated mutation 1, Pico Caroni
• MGI ID: MGI:8245329
• Synonyms: Syt2-Cre
• Gene: Syt2 Location: Chr1:134574319-134680887 bp, + strand Genetic Position: Chr1, 58.24 cM
• Alliance: Syt2^em1(cre)Crni page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Syt2^em1(cre)Crni expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Syt2 (MGI:99666)

• Mutation details: CRISPR/cas9 genome editing technology was used to insert a donor cassette containing an internal ribosome entry site, a Cre recombinase and an SV40 polyadenylation site into the 3'UTR region in exon 9. (J:372044)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Syt2 (mouse) Summary of all recombinase alleles driven by Syt2. Alliance mouse Syt2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syt2 Mutation: 36 strains or lines available

References

• Original: J:372044 Valbuena S, et al., Early time window for memory ensemble allocation specifically depending on activity in Syt2+ early-born parvalbumin interneurons. Cell Rep. 2025 Aug 26;44(8):116144
• All: 1 reference(s)