Ighg1^{em2(cre,-dre/ERT2)Rsky}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ighg1^{em2(cre,-dre/ERT2)Rsky}
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 2, Klaus Rajewsky
• MGI ID: MGI:8245160
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^{em2(cre,-dre/ERT2)Rsky} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ighg1^{em2(cre,-dre/ERT2)Rsky} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ighg1 (MGI:96446)

• Mutation details: sgRNAs were designed to target the 3' UTR of the immunoglobulin heavy constant gamma 1 (G1m marker) (Ighg) gene for insertion of a cassette containing IRES-Cre_T2A_DreERT2 (a cre recombinase and a dre recombinase sequence fused to a human estrogen receptor ligand binding domain). (J:101977)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ighg1 (mouse) Summary of all recombinase alleles driven by Ighg1. Alliance mouse Ighg1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 29 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)