Tacr1^em1(flpo)Ygs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tacr1^em1(flpo)Ygs
• Name: tachykinin receptor 1; endonuclease-mediated mutation 1, Yan-Gang Sun
• MGI ID: MGI:8244930
• Synonyms: Tacr1-flpo
• Gene: Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
• Alliance: Tacr1^em1(flpo)Ygs page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Tacr1^em1(flpo)Ygs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tacr1 (MGI:98475)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a 2A-flpo sequence before the stop codon of the last exon of the gene. (J:367773)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tacr1 (mouse) Summary of all recombinase alleles driven by Tacr1. Alliance mouse Tacr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacr1 Mutation: 38 strains or lines available

References

• Original: J:367773 Deng J, et al., The Parabrachial Nucleus Directly Channels Spinal Nociceptive Signals to the Intralaminar Thalamic Nuclei, but Not the Amygdala. Neuron. 2020 Sep 9;107(5):909-923.e6
• All: 2 reference(s)