Dpp4^{em1(Cre/ERT2)Seale}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dpp4^{em1(Cre/ERT2)Seale}
• Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Patrick Seale
• MGI ID: MGI:8244920
• Synonyms: Dpp4^CreER
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^{em1(Cre/ERT2)Seale} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Dpp4^{em1(Cre/ERT2)Seale} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dpp4 (MGI:94919)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a coding sequence for CreERT2, with a carboxy-terminal P2A peptide, into the first exon of the gene. (J:348728)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dpp4 (mouse) Summary of all recombinase alleles driven by Dpp4. Alliance mouse Dpp4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 72 strains or lines available

References

• Original: J:348728 Stefkovich M, et al., Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis. Mol Metab. 2021 Oct 15;54:101357
• All: 2 reference(s)