Trem2^{em1(cre,-EGFP)Fgnx}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trem2^{em1(cre,-EGFP)Fgnx}
• Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Florent Ginhoux
• MGI ID: MGI:8244872
• Synonyms: Trem2^CreEGFP
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^{em1(cre,-EGFP)Fgnx} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase, Reporter)
• Mutation: Insertion
• Trem2^{em1(cre,-EGFP)Fgnx} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trem2 (MGI:1913150)

• Mutation details: CRISPR-Cas9 genome editing technology was used to insert An IRES-Cre-2A-EGFP cassette into the into the exon 1 region of the gene. (J:362923)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trem2 (mouse) Summary of all recombinase alleles driven by Trem2. Alliance mouse Trem2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 64 strains or lines available

References

• Original: J:362923 Dunsmore G, et al., Timing and location dictate monocyte fate and their transition to tumor-associated macrophages. Sci Immunol. 2024 Jul 26;9(97):eadk3981
• All: 1 reference(s)