Il7r^{em1(tdTomato,-cre/ERT2)Fgnx}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il7r^{em1(tdTomato,-cre/ERT2)Fgnx}
• Name: interleukin 7 receptor; endonuclease-mediated mutation 1, Florent Ginhoux
• MGI ID: MGI:8244870
• Synonyms: Il7r^{tdTomato-creERT2}
• Gene: Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
• Alliance: Il7r^{em1(tdTomato,-cre/ERT2)Fgnx} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Il7r^{em1(tdTomato,-cre/ERT2)Fgnx} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il7r (MGI:96562)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert an IRES-tdTomato-2A-creERT2-Wpre-pA cassette into the 3 UTR of the Il7r gene. (J:371587)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il7r (mouse) Summary of all recombinase alleles driven by Il7r. Alliance mouse Il7r gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7r Mutation: 30 strains or lines available

References

• Original: J:371587 Zhu Y, et al., Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages. Nat Immunol. 2025 Jul 23
• All: 1 reference(s)