Klf4^{em1(EGFP,-cre/ERT2)Fgnx}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klf4^{em1(EGFP,-cre/ERT2)Fgnx}
• Name: Kruppel-like transcription factor 4 (gut); endonuclease-mediated mutation 1, Florent Ginhoux
• MGI ID: MGI:8244869
• Synonyms: Klf4^eGFP-creERT2
• Gene: Klf4 Location: Chr4:55527143-55532466 bp, - strand Genetic Position: Chr4, 29.76 cM
• Alliance: Klf4^{em1(EGFP,-cre/ERT2)Fgnx} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Klf4^{em1(EGFP,-cre/ERT2)Fgnx} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Klf4 (MGI:1342287)

• Mutation details: CRISPR/Cas9 genome editing technology was used to insert an IRES-eGFP-2A-creERT2-Wpre-pA cassette into the 3 UTR of the Klf4 gene. (J:371587)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Klf4 (mouse) Summary of all recombinase alleles driven by Klf4. Alliance mouse Klf4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf4 Mutation: 25 strains or lines available

References

• Original: J:371587 Zhu Y, et al., Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages. Nat Immunol. 2025 Jul 23
• All: 1 reference(s)