Ly6g^{tm1(cre/ERT2)Hida}
Targeted Allele Detail

Summary

• Symbol: Ly6g^{tm1(cre/ERT2)Hida}
• Name: lymphocyte antigen 6 family member G; targeted mutation 1, Andres Hidalgo
• MGI ID: MGI:8244801
• Synonyms: Ly6G^CreERT2
• Gene: Ly6g Location: Chr15:75027110-75030977 bp, + strand Genetic Position: Chr15, 34.29 cM, cytoband E1
• Alliance: Ly6g^{tm1(cre/ERT2)Hida} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298370
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ly6g^{tm1(cre/ERT2)Hida} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ly6g (MGI:109440)

• Mutation details: A creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by an SV40 polyadenylation signal, and an FRT-flanked neomycin resistance (neo) cassette was inserted into the exon 2 of the gene. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:298370)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ly6g (mouse) Summary of all recombinase alleles driven by Ly6g. Alliance mouse Ly6g gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ly6g Mutation: 22 strains or lines available

References

• Original: J:298370 Ballesteros I, et al., Co-option of Neutrophil Fates by Tissue Environments. Cell. 2020 Nov 25;183(5):1282-1297.e18
• All: 2 reference(s)