Ins1^{tm1.1(dre)Gkg}
Targeted Allele Detail

Summary

• Symbol: Ins1^{tm1.1(dre)Gkg}
• Name: insulin I; targeted mutation 1.1, George Gittes
• MGI ID: MGI:8244789
• Gene: Ins1 Location: Chr19:52252735-52253453 bp, + strand Genetic Position: Chr19, 46.76 cM
• Alliance: Ins1^{tm1.1(dre)Gkg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286822
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ins1^{tm1.1(dre)Gkg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ins1 (MGI:96572)

• Mutation details: The entire coding region and 3' UTR of the Ins1 gene, both located in exon 2, were replaced with a Dre gene and SV40 poly(A) sequences. An frt-flanked neo cassette was removed via FLP-mediated recombination in the germline. (J:286822)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ins1 (mouse) Summary of all recombinase alleles driven by Ins1. Alliance mouse Ins1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins1 Mutation: 49 strains or lines available

References

• Original: J:286822 Sehrawat A, et al., SMAD7 enhances adult beta-cell proliferation without significantly affecting beta-cell function in mice. J Biol Chem. 2020 Apr 10;295(15):4858-4869
• All: 1 reference(s)