Igha^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Igha^tm1Fwa
• Name: immunoglobulin heavy constant alpha; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:8243937
• Gene: Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM
• Alliance: Igha^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236459
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeted mutation incorporated a substitution of mouse V)H(81X (IGHV5-2) with human IGHVH1-2*02, a deletion of the intergenic control region 1 (IGCR1), and a replacement of mouse J)H(1-4 with human JH2 (J)H(b; IGHJ2*01) in Igha locus. The human IGVH1-2*02 insertion, IGCRI deletion, and human IGHJ2*01 insertion were also introduced into the Igha locus. (J:101977, J:236459)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igha Mutation: 22 strains or lines available

References

• Original: J:236459 Tian M, et al., Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 2016 Sep 8;166(6):1471-1484.e18
• All: 2 reference(s)