Iapp^{tm1.1(cre/GFP)Rpa}
Targeted Allele Detail

Summary

• Symbol: Iapp^{tm1.1(cre/GFP)Rpa}
• Name: islet amyloid polypeptide; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:8243420
• Gene: Iapp Location: Chr6:142244151-142249546 bp, + strand Genetic Position: Chr6, 73.81 cM
• Alliance: Iapp^{tm1.1(cre/GFP)Rpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Iapp^{tm1.1(cre/GFP)Rpa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Iapp (MGI:96382)

• Mutation details: Cre:GFP and an FRT-flanked SV40-neomycin cassette were inserted just 5' of the exon 2 initiation codon of the mouse Iapp gene through homologous recombination. The initiation codon and most of the signal sequence are deleted, thus this is likely a knock-out allele. FLP recombinase removed an FRT-flanked SV40-Neo cassette. (J:101977)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Iapp (mouse) Summary of all recombinase alleles driven by Iapp. Alliance mouse Iapp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iapp Mutation: 14 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)