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Ldhbtm1.2Choy
Targeted Allele Detail
Summary
Symbol: Ldhbtm1.2Choy
Name: lactate dehydrogenase B; targeted mutation 1.2, Yun-Hoon Choung
MGI ID: MGI:8242645
Gene: Ldhb  Location: Chr6:142435975-142453683 bp, - strand  Genetic Position: Chr6, 74.17 cM
Alliance: Ldhbtm1.2Choy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:371573
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked pgk-neo cassette and loxP site were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 3 via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of expression in heart and kidney from homozygous mice. (J:371573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldhb Mutation:  34 strains or lines available
References
Original:  J:371573 Tian C, et al., Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis. Cell Death Dis. 2020 May 15;11(5):375
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/29/2025
MGI 6.24
The Jackson Laboratory