Ldhbtm1.2Choy
Targeted Allele Detail
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Symbol: |
Ldhbtm1.2Choy |
Name: |
lactate dehydrogenase B; targeted mutation 1.2, Yun-Hoon Choung |
MGI ID: |
MGI:8242645 |
Gene: |
Ldhb Location: Chr6:142435975-142453683 bp, - strand Genetic Position: Chr6, 74.17 cM
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Alliance: |
Ldhbtm1.2Choy page
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Germline Transmission: |
Earliest citation of germline transmission:
J:371573
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked pgk-neo cassette and loxP site were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 3 via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of expression in heart and kidney from homozygous mice.
(J:371573)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ldhb Mutation: |
34 strains or lines available
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Original: |
J:371573 Tian C, et al., Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis. Cell Death Dis. 2020 May 15;11(5):375 |
All: |
2 reference(s) |
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