Krt13^{em1(cre/ERT2)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Krt13^{em1(cre/ERT2)Cya}
• Name: keratin 13; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:8235635
• Synonyms: Krt13^{em1(P2A-CreERT2)}
• Gene: Krt13 Location: Chr11:100008153-100012392 bp, - strand Genetic Position: Chr11, 63.41 cM
• Alliance: Krt13^{em1(cre/ERT2)Cya} page

Mutation origin

• Strain of Origin: C57BL/6JCya

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Krt13^{em1(cre/ERT2)Cya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt13 (MGI:101925)

• Mutation details: Krt13-CreERT2 allele are generated via genome editing by replacing the TAA stop codon of the mouse gene with a P2A-CreERT2 cassette. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with allele containing loxP sites, offspring are expected to undergo Cre-mediated recombination between loxP sites specifically in Krt13-positive cells following tamoxifen administration. (J:326541)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt13 (mouse) Summary of all recombinase alleles driven by Krt13. Alliance mouse Krt13 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt13 Mutation: 36 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)