Tmem138^tm1.2Cql
Targeted Allele Detail

Summary

• Symbol: Tmem138^tm1.2Cql
• Name: transmembrane protein 138; targeted mutation 1.2, Chunqiao Liu
• MGI ID: MGI:8235443
• Synonyms: Tmem138^c
• Gene: Tmem138 Location: Chr19:10547842-10554726 bp, - strand Genetic Position: Chr19, 6.6 cM, cytoband B
• Alliance: Tmem138^tm1.2Cql page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:369940
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 2 an FRT site, a splice acceptor, and an eGFP reporter gene, followed by a polyadenylation signal, a loxP site, and a neomycin resistance cassette with a 3' FRT site. It also inserted loxP sites surrounding exons 2 and 3. Flp-mediated recombination removed the reporter gene and selection cassette, leaving exons 2 and 3 floxed. (J:369940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem138 Mutation: 16 strains or lines available

References

• Original: J:369940 Guo D, et al., Tmem138 is localized to the connecting cilium essential for rhodopsin localization and outer segment biogenesis. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109934119
• All: 1 reference(s)