Drd2^tm1.1Jbaik
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1.1Jbaik
• Name: dopamine receptor D2; targeted mutation 1.1, Ja-Hyun Baik
• MGI ID: MGI:8234914
• Synonyms: Drd2^flox
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1.1Jbaik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:370704
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele carries loxP sites flanking exons 2, 3, and 4 of the Drd2 (dopamine receptor D2) gene. The upstream loxP site was inserted into intron 1, and the downstream loxP site into intron 4, enabling Cre-mediated excision of exons 2-4 to generate a null allele. The neomycin selection cassette was removed by FLP recombination prior to colony expansion. (J:370704)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:370704 Kim B, et al., Dopamine D2 receptor modulation of insulin receptor signaling in the central amygdala: implications for compulsive-like eating behavior. Molecular Psychiatry. 2025
• All: 1 reference(s)