Abhd15^em3Dejs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Abhd15^em3Dejs
• Name: abhydrolase domain containing 15; endonuclease-mediated mutation 3, David James
• MGI ID: MGI:8226235
• Synonyms: ABHD15^-
• Gene: Abhd15 Location: Chr11:77405943-77411454 bp, + strand Genetic Position: Chr11, 46.63 cM, cytoband B5
• Alliance: Abhd15^em3Dejs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 100 bp deletion in exon 1. Western blot analysis demonstrated a 90% or greater reduction of protein expression in epididymal visceral white adipose tissue (visWAT), subcutaneous WAT (scWAT), brown adipose tissue (BAT), as well as in isolated pancreatic islets and liver. (J:285457)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd15 Mutation: 16 strains or lines available

References

• Original: J:285457 Stockli J, et al., ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation. Mol Metab. 2019 Jul;25:83-94
• All: 1 reference(s)