Enpp6^tm1Aoki
Targeted Allele Detail

Summary

• Symbol: Enpp6^tm1Aoki
• Name: ectonucleotide pyrophosphatase/phosphodiesterase 6; targeted mutation 1, Junken Aoki
• MGI ID: MGI:8226230
• Synonyms: ENPP6^-, ENPP6 KO
• Gene: Enpp6 Location: Chr8:47439922-47549797 bp, + strand Genetic Position: Chr8, 26.48 cM
• Alliance: Enpp6^tm1Aoki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 containing the initiation methionine was replaced with a neomycin selection cassette. Immunostaining with an anti-ENPP6 monoclonal antibody revealed the absence of specific signals in the brain of homozygous mutant mice. (J:283191)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enpp6 Mutation: 32 strains or lines available

References

• Original: J:283191 Morita J, et al., Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Sci Rep. 2016 Feb 18;6:20995
• All: 1 reference(s)