Gt(ROSA)26Sor^{tm1(CAG-Got1)Chang}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Got1)Chang}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Ji Suk Chang
• MGI ID: MGI:8222071
• Synonyms: R26-Got1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Got1)Chang} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:369609
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Got1)Chang} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Got1 (MGI:95791)

• Mutation details: A targeting vector containing CAG-loxP-neo-3xpA (Stop)-loxP-Got1 cDNA was introduced to intron 1 of the mouse Gt(ROSA)26Sor gene via homologous recombination, (J:101977, J:369609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1210 strains or lines available

Notes

Es cells used are C57BL/6N-PRX-B6N #1 mES cells.

References

• Original: J:369609 Park CH, et al., Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids. Cell Rep. 2025 Jun 19;44(7):115888
• All: 2 reference(s)