Zdhhc19^em2Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zdhhc19^em2Osb
• Name: zinc finger, DHHC domain containing 19; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:8221407
• Synonyms: Zdhhc19^C142S
• Gene: Zdhhc19 Location: Chr16:32315059-32326032 bp, + strand Genetic Position: Chr16, 22.76 cM
• Alliance: Zdhhc19^em2Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details:

  CRISPR targeting inserted the mutation responsible for the amino acid substitution of cysteine with serine at position 142 (C142S), which ablates autoacylation of the DHHC domain and disrupts the palmitoyltransferase activity of ZDHHC19. Immunoblot analysis showed no detectable difference in the protein amount of ZDHHC19 in homozygous mutant testes. (J:366950)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc19 Mutation: 106 strains or lines available

References

• Original: J:366950 Kaneda Y, et al., TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122
• All: 1 reference(s)